GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs2739330 | 1 | rs2739330 | chr22:24295286 | LOC391322 | chr22:24373117-24374043:+ | 0.69 | 5.11 | 4.12E-6 | Liver enzyme levels (gamma-glutamyl transferase) |
| UVM | cis | rs1003719 | 1 | rs2835607 | chr21:38491973 | PIGP | chr21:38437664-38445458:- | -0.63 | -4.93 | 8.02E-6 | Eye color traits |
| UVM | cis | rs1003719 | 1 | rs2835608 | chr21:38493455 | PIGP | chr21:38437664-38445458:- | -0.63 | -4.93 | 8.02E-6 | Eye color traits |
| UVM | cis | rs10935120 | 1 | rs28409322 | chr3:134252385 | ANAPC13 | chr3:134196547-134204865:- | -0.46 | -6.87 | 6.1E-9 | Height |
| UVM | cis | rs10242455 | 1 | rs28468623 | chr7:98922812 | PTCD1 | chr7:99016751-99063808:- | 0.7 | 4.85 | 1.07E-5 | Blood metabolite levels |
| UVM | cis | rs11190604 | 1 | rs28522614 | chr10:102323141 | SEC31B | chr10:102246403-102289636:- | -0.39 | -4.75 | 1.48E-5 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs9902453 | 1 | rs28664971 | chr17:28437410 | EFCAB5 | chr17:28256874-28435469:+ | 0.43 | 5.84 | 2.91E-7 | Coffee consumption (cups per day) |
| UVM | cis | rs9876781 | 1 | rs2885510 | chr3:48418226 | TREX1 | chr3:48501186-48509043:+ | 0.4 | 4.97 | 6.82E-6 | Longevity |
| UVM | cis | rs10935120 | 1 | rs2887797 | chr3:134202506 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.01 | 3.68E-9 | Height |
| UVM | cis | rs2920503 | 1 | rs2920503 | chr3:12324230 | MKRN2 | chr3:12598594-12625208:+ | -0.33 | -5.13 | 3.86E-6 | LDL cholesterol |
| UVM | cis | rs2932538 | 1 | rs2932538 | chr1:113216543 | ST7L | chr1:113066142-113162405:- | -0.65 | -4.83 | 1.14E-5 | Systolic blood pressure;Hypertension;Diastolic blood pressure;Blood pressure |
| UVM | cis | rs979233 | 1 | rs2940927 | chr5:42422389 | C5orf51 | chr5:41904470-41921737:+ | -0.45 | -5.41 | 1.41E-6 | Systemic lupus erythematosus |
| UVM | cis | rs979233 | 1 | rs2940940 | chr5:42397230 | C5orf51 | chr5:41904470-41921737:+ | -0.45 | -5.41 | 1.41E-6 | Systemic lupus erythematosus |
| UVM | cis | rs979233 | 1 | rs2972396 | chr5:42407985 | C5orf51 | chr5:41904470-41921737:+ | -0.45 | -5.41 | 1.41E-6 | Systemic lupus erythematosus |
| UVM | cis | rs2985684 | 1 | rs2985684 | chr14:50101682 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |